Developing novel biomaterials for wound dressing applications using natural polymers and active substances with antimicrobial properties is beneficial for wound treatment. Cannabis oil is rich in many active compounds, and its main component—cannabidiol, provides antimicrobial, antioxidant, regenerative, and antithrombotic properties of beneficial properties for wound treatment. The current study presents the preparation and characterization of novel natural chitosan-based films incorporating cannabis oil for wound dressing. All chitosan-based film samples with cannabis oil exhibited good mechanical and hydrophilic properties and a high swelling ratio. Degradability tests showed that the films lost their maximum weight within eight days. Moreover, increased concentration of cannabis oil in the samples promoted adsorption of human albumin. The obtained biomaterials showed good antimicrobial activity against A. fischeri and a good drug release profile. In addition, cell culture studies demonstrated that designed CBD-CS biomaterials are biocompatible. Therefore, chitosan-based films incorporating cannabis oil might be an excellent candidate for wound treatment and dressing.
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